Saturday’s main event featuring a battle of two heavyweights looking to earn a UFC title shot was canceled Friday due to a positive COVID-19 test.

Curtis Blaydes was set to face Derrick Lewis in the main event of the Las Vegas ESPN2/ESPN+ show, but Blaydes tested positive for the coronavirus according to ESPN’s Ariel Helwani. The fight is likely to be remade for the much maligned UFC 256 pay-per-view on December 12th but that is unconfirmed.

The new main event is former light heavyweight title contender Anthony Smith vs. Devin Clark. The fight will still be five rounds instead of their originally scheduled three. Smith is coming off back-to-back losses and defeats in three of his last four while Clark is looking for his third straight win.

The loss of Blaydes vs. Lewis is the just the latest main event to fall through for the company in recent weeks.

The aforementioned UFC 256 show lost featherweight champion Amanda Nunes vs. Megan Anderson and then bantamweight champion Petr Yan vs. Aljamain Sterling. In early-November, Islam Makhachev had to withdraw from a main event with Rafael dos Anjos with UFC getting Paul Felder to fill in five days notice. That was preceded by December 5th headliner Darren Till getting injured and needing to be replaced by Kevin Holland for a Fight Night main event against Jack Hermansson.